Across the University of Texas System, a major shift in how sepsis recognized, measured, and treated is underway.
The UT-MOST (Managing and Optimizing Sepsis Treatment) initiative, led through the UT Health Intelligence Platform (UT-HIP), is moving from planning into action, bringing together clinicians, data, and leadership across UT hospitals to reduce preventable deaths from sepsis. Sepsis remains one of the leading causes of hospital mortality, where minutes can mean the difference between recovery and tragedy. UT-MOST was created to address this challenge not in isolation, but at scale, aligning care across an entire academic health system serving patients throughout Texas.
From Alignment to Action
Over the past year, UT-MOST established the foundation for systemwide improvement, including shared clinical definitions, aligned workflows, and a common approach to measurement. In 2026, the initiative is entering its most impactful phase. For the first time, the UT institutions are gaining the ability to see sepsis care patterns across hospitals, identify variation earlier in the patient journey, and turn shared insight into coordinated improvement. This moment marks a critical transition, from understanding the problem to measuring to improving it together.
Turning Data into Better Care
By integrating sepsis analytics into the broader UT-HIP data ecosystem, UT-MOST is enabling more timely insight into care delivery, treatment delays, and opportunities for improvement. These capabilities support faster recognition of high-risk patients and lay the groundwork for responsibly using advanced analytics and artificial intelligence to strengthen quality and consistency of care. UT-MOST has activated unprecedented collaboration across UT-owned and affiliated hospitals. Clinicians, nurses, pharmacists, informaticists, and executive leaders are now aligned around shared goals and shared accountability for outcomes.
What Comes Next
In the year ahead, UT-MOST will focus on delivering what matters most: faster treatment, reduced variation, and fewer lives lost to sepsis.
“UT-MOST demonstrates what becomes possible when an academic health system aligns around a single mission,” says Tim Kraeter, Director of Clinical Performance Improvement for Sepsis Outcomes at UT-HIP. “Our responsibility is clear, turning shared data and shared expertise into measurable improvements in patient survival.
Through UT-MOST, the University of Texas System is not only improving sepsis care within its hospitals; it is helping define the future of coordinated, data-driven clinical improvement for academic health systems nationwide.
